Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway

April 2024 in “ Journal of ethnopharmacology ”

Hangjie Fu, Wenxia Li, Jinyuan Liu, Qianqian Tang, Zhiwei Weng, Lijian Zhu, Bin Ding

ellagic acid dihydrotestosterone ferroptosis hair regeneration Wnt/β-catenin signaling pathway androgenic alopecia iron content lipid peroxidation mitochondrial dysfunction β-catenin knockdown dermal papilla cells EA DHT AGA Wnt signaling DPCs

TLDR Ellagic acid may help regrow hair and prevent hair loss by activating a specific cell growth pathway.

The study investigated the role of Ellagic Acid (EA) in promoting hair regeneration and inhibiting dihydrotestosterone (DHT)-induced ferroptosis in a mouse model of Androgenic Alopecia (AGA). EA, a polyphenol found in Paeonia lactiflora Pallas, was found to stimulate hair regeneration in mice and reverse DHT-induced increases in iron content, lipid peroxidation, and mitochondrial dysfunction by activating the Wnt/β-catenin signaling pathway. The study also found that β-catenin knockdown suppressed the inhibitory effect of EA on DHT-induced ferroptosis in dermal papilla cells (DPCs). The study concluded that EA has potential for use as a treatment option for AGA.

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