Suppression of Uterine and Placental Ferroptosis by N-Acetylcysteine in a Rat Model of Polycystic Ovary Syndrome

    November 2021 in “ Molecular Human Reproduction ”
    Min Hu, Yuehui Zhang, Shuting Ma, Juanli Li, Xu Wang, Mengmeng Liang, Amanda N. Sferruzzi‐Perri, Xiaoke Wu, Hongxia Ma, Mats Brännström, Ruijin Shao, Håkan Billig
    TLDR N-acetylcysteine may help treat uterine and placental issues in PCOS.
    The study investigated the effects of N-acetylcysteine (NAC) on uterine and placental ferroptosis in a rat model of polycystic ovary syndrome (PCOS) with hyperandrogenism and insulin resistance. NAC was found to attenuate ferroptosis in the uterus and placenta, with dose-dependent increases in anti-ferroptosis gene content and increased glutathione peroxidase 4 protein levels in the placenta. While NAC did not fully reverse mitochondria-morphological abnormalities in the uterus, it partially did so in the placenta. NAC also normalized specific mRNA expressions related to uterine and placental function. These findings suggested that NAC could be a potential therapeutic strategy for treating uterine and placental dysfunction in PCOS-related conditions.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 461 results

      community high bloodpressure and crown thinning in early 20s

      in Is this regrowth?  9 upvotes 1 year ago
      A user with kidney disease and high blood pressure experienced hair thinning, especially around the vertex. They are currently using finasteride and oral minoxidil but are considering whether to resume blood pressure medication despite managing symptoms with diet and exercise.

      community Creating the Holy Grail Hair Loss Topical

       1 upvotes 5 years ago
      The conversation is about creating a natural hair loss topical using ingredients like cetirizine, Zinc Sulphate Heptahydrate, Safflower Extract, Ricinoleic Acid, and others. The user is seeking input and collaboration on this topical formula.

      community Nothing's working, I feel depressed, also hopeless for the first time

      in Update  98 upvotes 2 years ago
      A user's experience with hair loss treatments, including Finasteride, Minoxidil, Nizoral Shampoo, Rosemary Oil, Vitamin D, Biotin, Vitamin C, Zinc and Dermarolling, that have not been successful over the past 14 months. Other users gave advice on how to cope with the issue, such as exercising, changing mindset, and shaving their head.

      community Some tips & advice from a long term finasteride + minoxidil user.

      in Chat  135 upvotes 3 years ago
      Long-term finasteride and minoxidil user shares tips for dealing with hair loss, including finding a shorter hairstyle, using finasteride, and not obsessing over hair. Users discuss washing frequency, alternative treatments, and focusing on other aspects of life.

      community Minokem-N cotains hydrocortisone?

      in Minoxidil  2 upvotes 8 months ago
      Minokem-N's composition is unclear, with concerns about unlisted hydrocortisone. Users discuss alternatives like AloATM, which lacks soothing agents, and the challenges of verifying ingredients.

    Similar Research

    5 / 1000+ results