Cyanidin-3-O-Glucoside And Its Derivative Vitisin A Alleviate Androgenetic Alopecia By Exerting Anti-Androgen Effect And Inhibiting Dermal Papilla Cell Apoptosis

    December 2023 in “ European Journal of Pharmacology
    Xiang Hu, Xusheng Li, Shengjun Wu, Xinwei Jiang, Guobing Chen, Hu Y, Jianxia Sun, Weibin Bai
    Image of study
    TLDR C3G and Vitisin A may help prevent hair loss by blocking male hormones and stopping hair cell death.
    The study investigates the potential of Cyanidin-3-O-glucoside (C3G) and its derivative Vitisin A in alleviating Androgenetic alopecia (AGA), a common cause of hair loss. The research suggests that C3G and Vitisin A, as active ingredients from natural products, play a role in alleviating AGA by exerting an anti-androgenic effect to inhibit the apoptosis of dermal papilla cells (HDPCs), changing the release of FGF7 and TGFβ1 of HDPCs, and activating the Wnt/β-catenin pathway to improve hair follicle proliferation. These compounds could potentially be used as a therapy for AGA and have scientific guiding significance for the daily maintenance of patients with AGA.
    Discuss this study in the Community →

    Research cited in this study

    24 / 24 results

    Related Community Posts Join

    2 / 2 results

    Similar Research

    5 / 77 results