Cyanidin-3-O-Glucoside And Its Derivative Vitisin A Alleviate Androgenetic Alopecia By Exerting Anti-Androgen Effect And Inhibiting Dermal Papilla Cell Apoptosis

December 2023 in “ European Journal of Pharmacology ”

Xiang Hu, Xusheng Li, Shengjun Wu, Xinwei Jiang, Guobing Chen, Hu Y, Jianxia Sun, Weibin Bai

Cyanidin-3-O-glucoside Vitisin A androgenetic alopecia anti-androgen effect dermal papilla cell apoptosis FGF7 TGFβ1 Wnt/β-catenin pathway hair follicle proliferation C3G AGA HDPCs

TLDR C3G and Vitisin A may help prevent hair loss by blocking male hormones and stopping hair cell death.

The study investigates the potential of Cyanidin-3-O-glucoside (C3G) and its derivative Vitisin A in alleviating Androgenetic alopecia (AGA), a common cause of hair loss. The research suggests that C3G and Vitisin A, as active ingredients from natural products, play a role in alleviating AGA by exerting an anti-androgenic effect to inhibit the apoptosis of dermal papilla cells (HDPCs), changing the release of FGF7 and TGFβ1 of HDPCs, and activating the Wnt/β-catenin pathway to improve hair follicle proliferation. These compounds could potentially be used as a therapy for AGA and have scientific guiding significance for the daily maintenance of patients with AGA.

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