Cyanidin-3-O-Glucoside And Its Derivative Vitisin A Alleviate Androgenetic Alopecia By Exerting Anti-Androgen Effect And Inhibiting Dermal Papilla Cell Apoptosis

    December 2023 in “ European Journal of Pharmacology ”
    Xiang Hu, Xusheng Li, Shengjun Wu … Weibin Bai
    Studysummary This study found that Cyanidin-3-O-glucoside and Vitisin A were able to penetrate mouse skin and improve issues related to hair follicle miniaturization and apoptosis in androgenetic alopecia, suggesting these compounds as potential alternative treatments for hair loss.
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    Research cited in this study 25

    1. Glycyrrhizin Micellar Nanocarriers for Topical Delivery of Baicalin to the Hair Follicles: A Targeted Approach Tailored for Alopecia Treatment International Journal of Pharmaceutics · 2022
    2. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    3. Natural Products for Male Androgenetic Alopecia Dermatologic Therapy · 2022
    4. Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study Turk Dermatoloji Dergisi · 2022
    5. Hormonal and Genetic Etiology of Male Androgenetic Alopecia Springer eBooks · 2022
    6. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    7. Reduction of Telogen Rate and Increase of Hair Density in Androgenetic Alopecia by a Cosmetic Product: Results of a Randomized, Prospective, Vehicle-Controlled Double-Blind Study in Men Journal of Cosmetic Dermatology · 2021
    8. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    9. Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase Biomedicine & Pharmacotherapy · 2021
    10. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    11. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    12. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    13. Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats Molecules · 2019
    14. Activating Wnt/β-Catenin Signaling Pathway for Disease Therapy: Challenges and Opportunities Pharmacology & Therapeutics · 2018
    15. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    16. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    17. Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited Molecular and Cellular Endocrinology · 2017
    18. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    19. Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer Journal of Agricultural and Food Chemistry · 2013
    20. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    21. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    22. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    23. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    24. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    25. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996