Combined Physicochemical and Transcriptomic Analyses Reveal the Effect of Black Wolfberry Ferment on Alopecia
May 2025
in “
Journal of Food and Nutrition Research
”
Studysummary In this study, black wolfberry ferment was found to promote hair regrowth in mice with androgenetic alopecia by increasing hair weight, follicle count, and skin thickness, potentially through PI3K/AKT, NF-kappa B, and MAPK signaling pathways. Our plain-language summary of this paper — not a Tressless recommendation.
This study investigated the effects of black wolfberry ferment on androgenetic alopecia (AGA) in mice, revealing that it promotes hair regrowth. Mice were divided into control, model, low-dosage, and high-dosage groups, with AGA induced in all but the control group. The ferment increased hair weight, hair follicle count, and skin thickness, with significant gene expression changes linked to the PI3K/AKT, NF-kappa B, and MAPK pathways. These findings suggest black wolfberry ferment as a potential therapeutic agent for AGA, supported by transcriptomic analysis identifying 1,636 relevant genes.
