A Comprehensive Review on Deep Eutectic Solvents and Their Use to Extract Bioactive Compounds of Pharmaceutical Interest

The review discusses the use of deep eutectic solvents (DESs) as green alternatives to traditional organic solvents for extracting bioactive compounds of pharmaceutical interest. DESs are praised for their low toxicity, biodegradability, and efficiency in extracting a wide range of bioactive compounds, including phenolics, flavonoids, and alkaloids. The paper highlights the environmental benefits, high solubilizing power, and customizable properties of DESs, which can improve extraction yields and selectivity while reducing energy consumption and environmental harm. Despite challenges in separating and recycling DESs on an industrial scale, new methods are being developed to address these issues. The review underscores the potential of DESs to replace conventional solvents in pharmaceutical extractions, promoting sustainability and reducing environmental impact.