Natural Phenylethanoid Glycoside Forsythoside A Alleviates Androgenetic Alopecia by Selectively Inhibiting TRPV3 Channels in Mice

The study investigates the effects of forsythoside A, a natural compound from Forsythia suspensa, on androgenetic alopecia, a common form of hair loss. Forsythoside A alleviates hair regrowth inhibition caused by dihydrotestosterone (DHT) by selectively inhibiting TRPV3 channels, which are upregulated in DHT-induced alopecia. The research demonstrates that both genetic and pharmacological inhibition of TRPV3 can effectively counteract hair growth inhibition. Forsythoside A's ability to target TRPV3 channels suggests its potential as a therapeutic approach for treating androgenetic alopecia, offering an alternative to current treatments like finasteride and minoxidil, which have notable side effects.