Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

    Kangjiao Yan, Xinghuai Sun, Gongxin Wang, Yani Liu, Kewei Wang
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    TLDR Activating TRPV3 channels stops hair growth by killing hair follicle cells.
    The study demonstrated that the TRPV3 channel, abundantly expressed in hair follicle outer root sheath (ORS) cells, played a crucial role in hair growth regulation. Activation of TRPV3 by carvacrol induced cell death in ORS cells and inhibited hair growth in mice. Conversely, inhibition of TRPV3 by forsythoside B or RNA interference reversed these effects, suggesting that TRPV3 inhibition could be a potential therapeutic approach for treating hair loss and hair follicle-related skin diseases.
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