Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

May 2019 in “ The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics ”

Kangjiao Yan, Xinghuai Sun, Gongxin Wang, Yani Liu, Kewei Wang

TRPV3 thermo–transient receptor potential vanilloid 3 hair follicle outer root sheath ORS cells carvacrol forsythoside B RNA interference hair growth regulation cell death hair follicle-related skin diseases RNAi

TLDR Activating TRPV3 channels stops hair growth by killing hair follicle cells.

The study demonstrated that the TRPV3 channel, abundantly expressed in hair follicle outer root sheath (ORS) cells, played a crucial role in hair growth regulation. Activation of TRPV3 by carvacrol induced cell death in ORS cells and inhibited hair growth in mice. Conversely, inhibition of TRPV3 by forsythoside B or RNA interference reversed these effects, suggesting that TRPV3 inhibition could be a potential therapeutic approach for treating hair loss and hair follicle-related skin diseases.

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