Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

The study demonstrated that the TRPV3 channel, abundantly expressed in hair follicle outer root sheath (ORS) cells, played a crucial role in hair growth regulation. Activation of TRPV3 by carvacrol induced cell death in ORS cells and inhibited hair growth in mice. Conversely, inhibition of TRPV3 by forsythoside B or RNA interference reversed these effects, suggesting that TRPV3 inhibition could be a potential therapeutic approach for treating hair loss and hair follicle-related skin diseases.