Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

    Kangjiao Yan, Xinghuai Sun, Gongxin Wang … Kewei Wang
    Studysummary This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.
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    Research cited in this study 18

    1. TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro Journal of Investigative Dermatology · 2018
    2. Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses Journal of Investigative Dermatology · 2018
    3. Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene Yonsei Medical Journal · 2018
    4. Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes Journal of Investigative Dermatology · 2017
    5. Regulation Mechanisms of Hair Growth Current problems in dermatology · 2015
    6. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    7. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    8. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    9. Seasonality of Hair Shedding in Healthy Women Complaining of Hair Loss Dermatology · 2009
    10. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    11. Hair Cycle Control by Vanilloid Receptor-1 (TRPV1): Evidence from TRPV1 Knockout Mice Journal of Investigative Dermatology · 2006
    12. A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control ˜The œAmerican journal of pathology (Print) · 2005
    13. Hair and Systemic Disease Dermatologic Clinics · 2001
    14. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    15. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    16. Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    17. Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    18. Hair Loss in Systemic Disease Dermatologic Clinics · 1987

    Related research 4

    1. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    2. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    3. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    4. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981