TRPV3 Ion Channel: From Gene to Pharmacology

May 2023 in “ International Journal of Molecular Sciences ”

Aleksandr P. Kalinovskii, L. L. Utkina, Yuliya V. Korolkova, Yaroslav A. Andreev

TRPV3 ion channel keratinocytes calcium homeostasis itch dermatitis hair growth skin regeneration inflammation thermal stimuli chemical stimuli agonists antagonists hair follicle regeneration TRPV3 inhibitors pruritus skin inflammation hair loss skin healing itch relief

TLDR The TRPV3 ion channel is important for skin and hair health and could be a target for treating skin conditions.

The review "TRPV3 Ion Channel: From Gene to Pharmacology" discusses the role of the TRPV3 ion channel, which is primarily expressed in keratinocytes and peripheral neurons. This channel is involved in calcium homeostasis and signaling pathways related to itch, dermatitis, hair growth, and skin regeneration. It is also associated with pathological dysfunctions, with increased expression in conditions of injury and inflammation. The TRPV3 channel can be activated by both thermal and chemical stimuli, and various natural and synthetic compounds can act as agonists or antagonists. The channel plays a significant role in hair growth and development, with underexpression leading to wavy hair and overexpression causing hair loss due to impaired hair follicle regeneration. The review also highlights the potential of TRPV3 inhibitors in the therapy of dermatitis and pruritus, and suggests that further study could lead to the development of target-selective drugs.

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