TLDR The TRPV3 ion channel is important for skin and hair health and could be a target for treating skin conditions.
The review "TRPV3 Ion Channel: From Gene to Pharmacology" discusses the role of the TRPV3 ion channel, which is primarily expressed in keratinocytes and peripheral neurons. This channel is involved in calcium homeostasis and signaling pathways related to itch, dermatitis, hair growth, and skin regeneration. It is also associated with pathological dysfunctions, with increased expression in conditions of injury and inflammation. The TRPV3 channel can be activated by both thermal and chemical stimuli, and various natural and synthetic compounds can act as agonists or antagonists. The channel plays a significant role in hair growth and development, with underexpression leading to wavy hair and overexpression causing hair loss due to impaired hair follicle regeneration. The review also highlights the potential of TRPV3 inhibitors in the therapy of dermatitis and pruritus, and suggests that further study could lead to the development of target-selective drugs.
28 citations,
September 2021 in “EMBO reports” Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.
11 citations,
August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.
12 citations,
May 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” Activating TRPV3 channels stops hair growth by killing hair follicle cells.
13 citations,
January 2018 in “Yonsei Medical Journal” A specific gene mutation causes Olmsted syndrome.
88 citations,
April 2012 in “Journal of Investigative Dermatology” Blocking TRPV3 may help treat itch in dry skin conditions.
105 citations,
May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Activating TRPV3 stops human hair growth.
59 citations,
September 2007 in “Biochemical and Biophysical Research Communications” The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
124 citations,
December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
77 citations,
September 2017 in “Journal of Investigative Dermatology” TRPV3 in skin cells causes inflammation and cell death.
105 citations,
May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Activating TRPV3 stops human hair growth.
12 citations,
May 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” Activating TRPV3 channels stops hair growth by killing hair follicle cells.
1 citations,
November 2023 in “International journal of molecular sciences” Cannabinoids might help treat skin problems but more research is needed to be sure.
