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    TRPV3 Ion Channel: From Gene to Pharmacology

    May 2023 in “ International Journal of Molecular Sciences ”
    Aleksandr P. Kalinovskii, L. L. Utkina, Yuliya V. Korolkova, Yaroslav A. Andreev
    Studysummary This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.
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    Research cited in this study 9

    1. Molecular Determinants for the Chemical Activation of the Warmth-Sensitive TRPV3 Channel by the Natural Monoterpenoid Carvacrol Journal of Biological Chemistry · 2022
    2. Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole EMBO reports · 2021
    3. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    4. Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath ˜The œjournal of pharmacology and experimental therapeutics/˜The œJournal of pharmacology and experimental therapeutics · 2019
    5. Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene Yonsei Medical Journal · 2018
    6. TRPV3 as a Therapeutic Target for Itch Journal of Investigative Dermatology · 2012
    7. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    8. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    9. Influence of TRPV3 Mutation on Hair Growth Cycle in Mice Biochemical and Biophysical Research Communications · 2007