Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole

    September 2021 in “ EMBO reports ”
    Arthur Neuberger, Kirill D. Nadezhdin, Eleonora Zakharian, Alexander I. Sobolevsky
    Studysummary In this study, researchers used cryo-electron microscopy to reveal how the natural compound osthole inhibits TRPV3 channels by binding to specific sites, changing the channel's conformation.
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    Research cited in this study 4

    1. Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole EMBO reports · 2021
    2. Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes Journal of Investigative Dermatology · 2017
    3. TRPV3 as a Therapeutic Target for Itch Journal of Investigative Dermatology · 2012
    4. Influence of TRPV3 Mutation on Hair Growth Cycle in Mice Biochemical and Biophysical Research Communications · 2007