Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole
September 2021
in “
EMBO reports
”
TLDR Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.
The study explores how the plant-derived coumarin osthole inhibits the TRPV3 channel, which is involved in hair growth and other physiological processes. Using cryo-electron microscopy, researchers identified that osthole binds to specific sites on the TRPV3 channel, causing conformational changes that stabilize its closed state and inhibit its activity. This structural insight into TRPV3 inhibition by osthole can guide the development of new drugs for treating TRPV3-related conditions, such as hair loss and skin disorders.
