Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

September 2007 in “ Biochemical and Biophysical Research Communications ”

Kohei Imura, Takeshi Yoshioka, Ichiro Hikita, Kiyoshi Tsukahara, Tsutomu Hirasawa, Kenichi Higashino, Yoshinari Gahara, Akinori Arimura, Tsuneaki Sakata

TRPV3 hair growth cycle anagen phase telogen phase keratin-associated protein gene alopecia androgen effects skin inflammation high fever hair growth hair loss hair development

TLDR The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

The 2007 study explored the impact of a TRPV3 gene mutation on hair growth in DS-Nh mice, a model for human atopic dermatitis. The mutation resulted in an increased thermal response and a reduction in anagen-related keratin-associated protein gene expression. Histological analysis revealed that DS-Nh mice maintained the anagen phase of hair growth, while DS mice entered the telogen phase at 21 days old. The findings suggest that TRPV3 plays a crucial role in hair development and could be a potential target for treating alopecia related to high fever, skin inflammation, or androgen effects. The exact number of mice used in the study was not provided.

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research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

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The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.