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Glossary Androgen Effects

biological impacts of male sex hormones like testosterone

Androgen effects refer to the biological impacts of androgens, which are male sex hormones like testosterone. These effects include the development of male characteristics such as facial hair, deeper voice, and muscle mass. In both men and women, androgens also influence hair growth patterns and can contribute to conditions like androgenetic alopecia (pattern baldness).

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Research

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research The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?

34 citations , July 2020 in “Frontiers in immunology”

This mini-review discusses the role of androgens, specifically testosterone and dihydrotestosterone, in the pathogenesis of autoimmune liver diseases and reports no new results.

research THE EFFECT OF SPIRONOLACTONE ON HIRSUTISM AND FEMALE ANDROGEN METABOLISM

32 citations , August 1985 in “Clinical endocrinology”

This study concluded that spironolactone may be an effective therapy for a subgroup of hirsute patients, as it reduced plasma testosterone and improved certain hair growth measures.

research Androgen effects on the skin

July 2015 in “Cambridge University Press eBooks”

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

research The Effect of the Aqueous Extract of Bidens Pilosa L. on Androgen Deficiency Dry Eye in Rats

27 citations , January 2016 in “Cellular Physiology and Biochemistry”

This study found that the extract of Bidens pilosa L. improved dry eye symptoms associated with androgen deficiency in rats by enhancing tear production, stabilizing the tear film, and reducing lacrimal gland inflammation.

research The Effects of Perinatal Androgen Deprivation on Body Weight and Spatial Working Memory in Male Rats

April 2015 in “The FASEB Journal”

This study observed that perinatal androgen deprivation in male rats increased serum estrogen levels, which was associated with improved spatial working memory and increased body weight.

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Community Join

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community Bicalutamide effect on androgens?

5 upvotes 5 years ago

Bicalutamide blocks androgen receptors, preventing testosterone and DHT from binding, which can help with hair loss but may cause feminization. It is not recommended for those who do not want feminization effects.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community Ranking of all the topical anti androgens in terms of effectivness?

5 upvotes 3 years ago

There is no reliable ranking for the effectiveness of topical anti-androgens like Fluridil, RU58841, and Pyrilutamide, with limited studies available. Some users suggest Pyrilutamide may be promising based on ongoing trials, while Fluridil combined with finasteride has shown positive results for some individuals.

community Minoxidil is able to suppress androgen receptors or increase aromatase effect. Blood test in pictures.

in Minoxidil 6 upvotes 4 years ago

A 24-year-old male experienced an increase in estradiol levels and symptoms like gynecomastia and excessive sweating after using Minoxidil for hair loss. His estradiol levels decreased after he stopped using Minoxidil.

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Learn

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Why are some women using bicalutamide to fight hormonal hair loss? Bicalutamide blocks androgens, helping women combat hormonal hair loss effectively.

learn Fluridil

a topical anti-androgen with less systemic involvement

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Baicapil

Losing hair from hormonal imbalance? Baicapil might block DHT without messing with your hormones. No published study shows that Baicapil blocks DHT — the only data on the ingredient itself is the manufacturer's own unpublished dossier, and the baicalin research behind the claim is cancer cell-line work in which the effect was explicitly independent of the androgen receptor.

learn Spironolactone

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

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