TLDR Blocking TRPV3 may help treat itch in dry skin conditions.
The study investigated the role of TRPV3 in itch using ICRTRPV3-/- mice and found that TRPV3 deletion significantly reduced spontaneous scratching behavior and nerve fiber density in the skin, despite no difference in dry skin development between TRPV3 knockout and wild-type mice. These findings suggested that TRPV3 played a crucial role in itch development and nerve sprouting in dry skin, indicating that TRPV3 antagonists could be a potential therapeutic option for managing pruritus in conditions like atopic dermatitis.
94 citations,
January 2016 in “Journal of the European Academy of Dermatology and Venereology” Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.
2 citations,
May 2023 in “International Journal of Molecular Sciences” The TRPV3 ion channel is important for skin and hair health and could be a target for treating skin conditions.
75 citations,
August 2018 in “Biochemical pharmacology” Targeting the skin's endocannabinoid system could help treat skin disorders.
3 citations,
December 2022 in “Cells” Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
124 citations,
December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
