TRPV3 as a Therapeutic Target for Itch

April 2012 in “ Journal of Investigative Dermatology ”

Erika Yamamoto‐Kasai, Kohei Imura, Kiyoshi Yasui, Michitaka Shichijou, I Oshima, Tsutomu Hirasawa, Tsuneaki Sakata, Takeshi Yoshioka

TRPV3 itch dry skin atopic dermatitis ICRTRPV3-/- mice nerve fiber density pruritus histamine H1R antagonist TRPV3 antagonists AD

TLDR Blocking TRPV3 may help treat itch in dry skin conditions.

The study investigated the role of TRPV3 in itch using ICRTRPV3-/- mice and found that TRPV3 deletion significantly reduced spontaneous scratching behavior and nerve fiber density in the skin, despite no difference in dry skin development between TRPV3 knockout and wild-type mice. These findings suggested that TRPV3 played a crucial role in itch development and nerve sprouting in dry skin, indicating that TRPV3 antagonists could be a potential therapeutic option for managing pruritus in conditions like atopic dermatitis.

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