TRPV3 as a Therapeutic Target for Itch

April 2012 in “ Journal of Investigative Dermatology ”

Erika Yamamoto‐Kasai, Kohei Imura, Kiyoshi Yasui, Michitaka Shichijou, I Oshima, Tsutomu Hirasawa, Tsuneaki Sakata, Takeshi Yoshioka

TRPV3 itch dry skin atopic dermatitis ICRTRPV3-/- mice nerve fiber density pruritus histamine H1R antagonist TRPV3 antagonists AD

TLDR Blocking TRPV3 may help treat itch in dry skin conditions.

The study explored the role of TRPV3 in itch associated with dry skin conditions like atopic dermatitis (AD). Using ICRTRPV3-/- mice, researchers found that TRPV3 deletion reduced spontaneous scratching behavior and nerve fiber density in the skin, suggesting TRPV3's involvement in pruritus. Despite no observed differences in dry skin development between TRPV3-deficient and normal mice, the findings indicated that TRPV3 could be a therapeutic target for histamine H1R antagonist-resistant pruritus. The study highlighted the potential of TRPV3 antagonists in managing AD and dry skin-related itch.

View this study on jidonline.org →