Pathogenesis and Management of TRPV3-Related Olmsted Syndrome

    December 2024 in “ Frontiers in Genetics ”
    Aobo Lu, Kezhen Li, Cong Huang … Weilong Zhong
    Studysummary This review discusses the genetic causes and pathogenesis of Olmsted syndrome, emphasizing the potential for a genotype-phenotype correlation due to TRPV3 mutations, and explores avenues for individualized treatment developments for this condition.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole EMBO reports · 2021
    2. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    3. Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath ˜The œjournal of pharmacology and experimental therapeutics/˜The œJournal of pharmacology and experimental therapeutics · 2019
    4. Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes Journal of Investigative Dermatology · 2017
    5. Expanding The Phenotypic Spectrum Of Olmsted Syndrome Journal of Investigative Dermatology · 2015
    6. TRPV3 as a Therapeutic Target for Itch Journal of Investigative Dermatology · 2012
    7. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    8. Influence of TRPV3 Mutation on Hair Growth Cycle in Mice Biochemical and Biophysical Research Communications · 2007