Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

    March 2021 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Zhen Song, Xi Chen, Qian Zhao … Yang Yong
    Studysummary This study found that hair loss in an Olmsted syndrome mouse model with a <i>Trpv3</i> mutation was linked to premature keratinocyte maturation, affecting hair follicle structure and function.
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    Research cited in this study 18

    1. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020
    2. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    3. Development of Hair Fibers Advances in experimental medicine and biology · 2018
    4. Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene Yonsei Medical Journal · 2018
    5. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017
    6. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    7. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    8. Detection of Bim and Puma in Mouse Hair Follicles Using Immunofluorescence and TUNEL Assay Double Staining Biotechnic & histochemistry · 2015
    9. Planar Cell Polarity Effector Gene Intu Regulates Cell Fate-Specific Differentiation of Keratinocytes Through the Primary Cilia Cell death and differentiation · 2012
    10. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    11. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    12. Influence of TRPV3 Mutation on Hair Growth Cycle in Mice Biochemical and Biophysical Research Communications · 2007
    13. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005
    14. Fine Structure and Immunocytochemistry of Monotreme Hairs, with Emphasis on the Inner Root Sheath and Trichohyalin-Based Cornification During Hair Evolution Journal of morphology · 2004
    15. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    16. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    17. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    18. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997

    Related research 5

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