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Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

12 citations , February 2014 in “PLoS ONE”

This study observed high expression of mTOR pathway effectors in fibrous papules and TSC-associated angiofibromas, suggesting that topical rapamycin might be an effective treatment for fibrous papules.

research Network pharmacology and molecular docking analysis on potential molecular targets and mechanism of action of BRAF inhibitors for application in wound healing

11 citations , June 2023 in “Journal of Cellular Biochemistry”

This study suggests that BRAF inhibitors, particularly Encorafenib and Dabrafenib, may have potential applications in wound healing by targeting specific proteins involved in the healing process in murine models.

research The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

177 citations , March 2018 in “International Journal of Molecular Sciences”

This review discusses the role of mTOR kinase in pulmonary fibrosis and explores how mTOR inhibitors may help slow the progression of this condition, but it reports no new results.

research Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles

28 citations , November 2012 in “Experimental dermatology”

This study suggests that mTORC1 may play a role in regulating the timing of hair growth cycle phases, particularly the initiation of the anagen phase.

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

42 citations , April 2012 in “Seminars in Oncology”

This review discusses the skin side effects associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for empirical management based on expert opinion.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community A Novel Synergistic Strategy for Hair Loss Prevention and Reversal: Rapamycin, Finasteride, and Minoxidil

40 upvotes 9 months ago

Rapamycin, finasteride, and minoxidil are discussed as a strategy for hair loss prevention and reversal. Pulsed dosing of rapamycin is suggested to avoid conflicting effects with minoxidil.

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

What is rapamycin, and how is it being studied as a potential treatment for hair loss? Rapamycin is being studied for hair loss due to its effects on the mTOR pathway.
Can rapamycin be combined with other treatments like minoxidil or finasteride for better results? There are no published human trials of rapamycin combined with minoxidil or finasteride; the case for combining them is mechanistic theory only, and rapamycin for hair loss remains an off-label use of an immunosuppressant, so any combination is a decision for a prescriber.
Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.
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Hair Transplant Surgeon
Dr. Rahma Targett, MD, FRACGP
Adelaide, SA, Australia

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Dr. Rahma Targett, MD, FRACGP