TLDR Ustekinumab successfully treated a man's resistant skin condition when other treatments failed.
This document reported a case of a 70-year-old man with treatment-resistant pityriasis rubra pilaris (PRP) who achieved complete clinical remission after six months of treatment with ustekinumab, an IL12/23 inhibitor. The patient had previously failed multiple treatments, including methotrexate, acitretin, ciclosporin, and mycophenolate. Ustekinumab was chosen due to a positive Quantiferon gold test, indicating latent TB, which made tumor necrosis factor inhibitors (TNFi) unsuitable due to the risk of reactivating TB. This case contributed to the literature supporting the use of biologic therapy, specifically IL12/23 inhibitors, for PRP when TNFi are contraindicated.
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