Mechanisms of Proton Inhibition and Sensitization of the Cation Channel TRPV3

    December 2020 in “ The Journal of General Physiology ”
    Haiyuan Wang, Yang Pu, Yungang Lu … Michael X. Zhu
    Studysummary This study found that acid regulation of the TRPV3 channel can inhibit its function from outside the cell while facilitating it from inside, providing insights into skin barrier and disorder mechanisms related to tissue acidosis.
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    Research cited in this study 4

    1. Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath ˜The œjournal of pharmacology and experimental therapeutics/˜The œJournal of pharmacology and experimental therapeutics · 2019
    2. Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes Journal of Investigative Dermatology · 2017
    3. Expanding The Phenotypic Spectrum Of Olmsted Syndrome Journal of Investigative Dermatology · 2015
    4. Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3 Journal of Investigative Dermatology · 2014