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research TRPV3 Ion Channel: From Gene to Pharmacology

2 citations , May 2023 in “International Journal of Molecular Sciences”

This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.

research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

77 citations , September 2017 in “Journal of Investigative Dermatology”

This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.

research Molecular determinants for the chemical activation of the warmth-sensitive TRPV3 channel by the natural monoterpenoid carvacrol

24 citations , February 2022 in “Journal of Biological Chemistry”

This study found that carvacrol activates the TRPV3 ion channel by binding to a specific pocket formed by the S2-S3 linker, providing insight into its role in skin sensitization and potential for designing specific modulators.

research Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching

7 citations , April 2015 in “Journal of biological chemistry/The Journal of biological chemistry”

This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.

research Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3

10 citations , May 2024 in “BioEssays”

This review examined the role of the ion channel TRPV3 in warmth sensation and skin physiology, discussing controversies around its direct contribution to temperature perception, its involvement in skin health, and its potential as a therapeutic target for skin diseases.

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community Progress pictures. 2 months on Fin, 4 on Min.

in Progress Pictures 191 upvotes 1 year ago

The user experienced significant hair regrowth after using Finasteride for 2 months and Minoxidil for 4 months, along with a derma roller. They reported no side effects from the treatments and noted that Finasteride seemed to contribute most to the progress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 1 year ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

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