Glycyrrhizin Micellar Nanocarriers for Topical Delivery of Baicalin to the Hair Follicles: A Targeted Approach Tailored for Alopecia Treatment

August 2022 in “ International Journal of Pharmaceutics ”

Quanfu Zeng, Zhuxian Wang, Zhaoming Zhu, Yi Hu, Yuan Wang, Yaqi Xue, Yufan Wu, Yinglin Guo, Peiyi Liang, Hongkai Chen, Zeying Zheng, Chunyan Shen, Cuiping Jiang, Hongxia Zhu, Qun Shen, Yankui Yi, Hui Li, Zhijun Yang, Li Liu, Qiang Liu

glycyrrhizin micellar nanocarriers baicalin androgenetic alopecia GL-BC nanomicelles GL-TW-BC nanomicelles Wnt/β-catenin pathway dermal papilla cells AGA hair follicles skin permeability bioavailability cellular uptake hair growth

TLDR Glycyrrhizin nanocarriers effectively deliver baicalin to hair follicles, promoting hair growth and offering a promising alopecia treatment with fewer side effects.

The study explored the use of glycyrrhizin (GL) micellar nanocarriers for the topical delivery of baicalin (BC) to hair follicles as a treatment for androgenetic alopecia (AGA). GL was used to encapsulate BC, forming GL-BC and GL-TW-BC nanomicelles, which improved BC's skin permeability, bioavailability, and cellular uptake. These formulations significantly enhanced BC penetration and accumulation in porcine skin via hair follicle pathways without causing skin irritation, offering a targeted and site-specific treatment. The study demonstrated that these nanomicelles could synergistically promote hair growth by activating the Wnt/β-catenin pathway and enhancing dermal papilla cell activity, providing a promising alternative to existing alopecia treatments with fewer side effects.

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