The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

    March 2016 in “ Advanced Pharmaceutical Bulletin ”
    Zahra Mardhiah Adib, Saeed Ghanbarzadeh, Maryam Kouhsoltani … Hamed Hamishehkar
    Studysummary This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.
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    Research cited in this study 6

    1. Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2015
    2. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    3. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    4. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    5. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    6. Dermal Delivery of Topically Applied Oligonucleotides via Follicular Transport in Mouse Skin Journal of Investigative Dermatology · 2005