Hyperandrogenism and Insulin Resistance Modulate Gravid Uterine and Placental Ferroptosis in PCOS-Like Rats

June 2020 in “ Journal of Endocrinology ”

Yuehui Zhang, Min Hu, Wenyan Jia, Guoqi Liu, Jiao Zhang, Bing Wang, Juan Li, Peng Cui, Xin Li, Susanne Lager, Amanda N. Sferruzzi‐Perri, Yanhua Han, Songjiang Liu, Xiaoke Wu, Mats Brännström, Ruijin Shao, Håkan Billig

hyperandrogenism insulin resistance ferroptosis PCOS 5α-dihydrotestosterone DHT GPX4 glutathione oxidative stress apoptosis necroptosis polycystic ovary syndrome dihydrotestosterone

TLDR Hyperandrogenism and insulin resistance in PCOS-like rats can lead to pregnancy complications due to increased cell death in the uterus and placenta.

The study investigated the effects of hyperandrogenism and insulin resistance on ferroptosis in the gravid uterus and placenta of PCOS-like rats, using 39 female rats. Exposure to 5α-dihydrotestosterone (DHT) and insulin led to decreased GPX4 and glutathione levels, increased oxidative stress, and altered ferroptosis-related gene expression, particularly in the uterus. These changes contributed to fetal loss, with apoptosis and necroptosis also playing compensatory roles. The study highlighted the complex interactions between hyperandrogenism, insulin resistance, and cell death pathways, suggesting potential impacts on pregnancy outcomes in PCOS.

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Research cited in this study

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research Comprehensive Overview of Polycystic Ovary Syndrome

883 citations , August 2016 in “Nature Reviews Disease Primers”

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

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research Current Aspects of Polycystic Ovary Syndrome: A Literature Review

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Polycystic ovary syndrome is a common hormonal disorder in women, linked to increased risk of metabolic and heart diseases, and needs more research for better understanding and treatment.

research Polycystic Ovary Syndrome and Acne

10 citations , January 2011 in “Skin therapy letter”

Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.

research The Diagnosis of Polycystic Ovary Syndrome in Adolescents

212 citations , May 2010 in “American Journal of Obstetrics and Gynecology”

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

Hyperandrogenism and Insulin Resistance Modulate Gravid Uterine and Placental Ferroptosis in PCOS-Like Rats

Research cited in this study

research Comprehensive Overview of Polycystic Ovary Syndrome

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