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Glossary Necroptosis

Necroptosis is a form of programmed cell death that is distinct from apoptosis, characterized by the swelling of cells and the release of pro-inflammatory signals. It plays a significant role in various biological processes, including tissue homeostasis and response to stress, and has been implicated in hair follicle biology and hair loss conditions. In the context of hair loss, necroptosis may contribute to the degeneration of hair follicle cells, influencing conditions such as alopecia. Key distinguishing characteristics of necroptosis include its reliance on specific signaling pathways, such as the receptor-interacting protein kinases (RIPK1 and RIPK3), which differentiate it from other forms of cell death.

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research 0960 Evidence for resident memory T cells and necroptosis as drivers of fibrosis in eosinophilic fasciitis and morphea

July 2025 in “Journal of Investigative Dermatology”

Resident memory T cells and necroptosis may drive fibrosis in eosinophilic fasciitis and morphea.

research LB1009 Baicalin, a component of the herbal medicine Baikal skullcap, inhibits epidermal necroptosis in SJS/TEN

July 2024 in “Journal of Investigative Dermatology”

In this study, baicalin, a component of Baikal skullcap, was found to inhibit necroptosis in a cellular model of toxic epidermal necrolysis, suggesting it may be effective against severe drug-induced skin eruptions.

research Necrobiosis Lipoidica

27 citations , December 1999 in “American Journal of Dermatopathology”

This case report presents a patient with necrobiosis lipoidica exhibiting transepithelial elimination of cholesterol crystals through hair follicles, a finding previously associated with necrobiotic xanthogranuloma.

research Atypical necrobiosis lipoidica of the face

7 citations , May 1978 in “Acta Dermato Venereologica”

This case report details a 36-year-old man with atypical necrobiosis lipoidica on his face, characterized by annular lesions and prominent giant cells without clear granuloma formation.

research Necrobiosis lipoidica of the scalp

September 2023 in “Russian Journal of Skin and Venereal Diseases”

This study reported a rare case of necrobiosis lipoidica occurring on the scalp, leading to scarring alopecia, and highlighted a positive response to glucocorticoid therapy by reducing the brightness and growth of plaques over one month.

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