LB1009 Baicalin, A Component Of The Herbal Medicine Baikal Skullcap, Inhibits Epidermal Necroptosis In SJS/TEN
July 2024
in “
Journal of Investigative Dermatology
”
New to baikal skullcap? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, baicalin, a component of Baikal skullcap, was found to inhibit necroptosis in a cellular model of toxic epidermal necrolysis, suggesting it may be effective against severe drug-induced skin eruptions. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigates the effects of baicalin, a component of the herbal medicine Baikal skullcap, on inhibiting necroptosis in Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Necroptosis, a form of programmed cell death, is implicated in the pathogenesis of SJS/TEN. The research utilized TEN model cells, where baicalin's inhibitory activity was assessed by measuring phosphorylated RIP3 levels and caspase-3 activity. Results showed that increasing concentrations of baicalin led to a decrease in phosphorylated RIP3 and caspase-3 activity, indicating its potential to inhibit necroptosis. This suggests that baicalin could be effective in treating severe drug-induced skin eruptions.
