Near-Infrared Light-Triggered Nitric Oxide-Releasing Hyaluronic Acid Hydrogel for Precision Transdermal Therapy of Androgenic Alopecia

The study presents a novel near-infrared (NIR) light-triggered nitric oxide (NO)-releasing hyaluronic acid hydrogel (Gel@L-Arg) for treating androgenic alopecia (AGA). This system allows for controlled NO release, overcoming its short half-life and enabling precise concentration adjustments. Under NIR light, the hydrogel releases NO, which enhances cell viability, reduces inflammation, and promotes angiogenesis, effectively improving the follicular microenvironment in AGA. The hydrogel demonstrated significant therapeutic effects in both in vitro and animal models, offering a promising non-invasive treatment strategy for AGA with good biocompatibility.