Light-Activatable Hyaluronic Acid Derivatives Releasing Nitric Oxide and Their Delivery in the Skin

    April 2025 in “ Advanced Healthcare Materials ”
    Giuseppe Longobardi, Cristina Parisi, Federica Sodano … Fabiana Quaglia
    Studysummary In this study, researchers developed hyaluronic acid derivatives functionalized with nitric oxide photodonors for light-activated skin treatments, finding that the compounds released NO under blue light and enhanced keratinocyte proliferation and migration, suggesting potential for therapeutic use.
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    Research cited in this study 4

    1. Near-Infrared Light-Triggered Nitric Oxide-Releasing Hyaluronic Acid Hydrogel for Precision Transdermal Therapy of Androgenic Alopecia International Journal of Biological Macromolecules · 2025
    2. Understanding Microemulsions and Nanoemulsions in Transdermal Delivery AAPS PharmSciTech · 2025
    3. Nitric Oxide Signal Transduction and Its Role in Skin Sensitization Biomolecules & therapeutics · 2023
    4. Highlighting Nuances of Blue Light Phototherapy: Mechanisms and Safety Considerations Journal of Biophotonics · 2022