TLDR Smaller curcumin nanocrystals penetrate skin better, but additives and particle size affect absorption and accumulation.
The study investigated the combined effects of delivery vehicle, penetration enhancer, and particle size on the skin passive permeation and hair follicle accumulation of curcumin nanocrystals (CUR-NCs). Three different particle sizes of CUR-NCs (60, 120, and 480 nm) were added to formulations containing propylene glycol (PG) and/or xanthan gum (XG). The results showed that the effects of the delivery vehicle on drug delivery are complex, as it controls the thermodynamic activity of the drug, which influences the diffusion coefficient of the drug. The study concluded that the size of the nanocrystals, the properties of the delivery vehicles, and the use of penetration enhancers all play a significant role in the effectiveness of dermal drug delivery.
Cited in this study
7 / 7 results
10 citations
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February 2022 in “Pharmaceuticals” Smaller curcumin nanocrystals penetrate skin and hair follicles better than larger ones.
18 citations
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December 2021 in “Colloids and surfaces. B, Biointerfaces” Nanoparticles can effectively deliver spironolactone to hair follicles for treating alopecia and acne.
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October 2021 in “European journal of pharmaceutics and biopharmaceutics” Nanoparticles sized between 470 and 750 nm are best for delivering substances like caffeine into hair follicles for absorption.
32 citations
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November 2020 in “Nanomaterials” Excipients greatly affect how well curcumin nanocrystals penetrate the skin and target hair follicles.
26 citations
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May 2020 in “International Journal of Biological Macromolecules” Chitosan-coated dutasteride nanocapsules improve hair treatment, and physical stimulation boosts effectiveness.
263 citations
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February 2013 in “Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology” Polymeric nanoparticles show promise for treating skin diseases.
263 citations
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February 2011 in “Journal of Controlled Release” Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.
