Formulation and Evaluation of PLGA Nanoparticulate-Based Microneedle System for Potential Treatment of Neurological Diseases

The study investigates a novel PLGA nanoparticulate-based microneedle system for transdermal drug delivery targeting neurological diseases, specifically aiming to enhance drug delivery across the blood-brain barrier (BBB). The microneedles, tested in vivo on Balb/c-nu/nu mice and ex vivo on Sprague-Dawley rats, demonstrated superior mechanical strength and drug delivery efficiency compared to traditional methods. The system effectively delivered drugs to the brain, as indicated by increased fluorescence intensity in the brain and hippocampus. The microneedles create micropore channels in the skin, allowing for efficient drug penetration and release. The study concludes that this system offers a promising non-invasive approach for CNS drug delivery, potentially overcoming the limitations of traditional invasive methods, although further research is needed to confirm these results in human models.