Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics

    Sasin Charoensuksira, Supasit Tantiwong, Juthapa Pongklaokam … Saranyoo Ponnikorn
    Studysummary The study investigated immune cell patterns around the hair follicle infundibulum in androgenetic alopecia, revealing significant differences in immune signatures between patients with AGA and control donors, specifically noting an enrichment of CD4 cells in the patient group.
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    Research cited in this study 38

    1. The Inflammatory Component of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    2. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia Microorganisms · 2021
    3. Pattern Hair Loss: Assessment of Microinflammation in Miniaturized and Terminal Hair Follicles Through Horizontal Histologic Sections Journal of The American Academy of Dermatology · 2020
    4. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    5. Immune Cell Regulation of the Hair Cycle Experimental Dermatology · 2020
    6. Female Pattern Hair Loss: An Update Indian Dermatology Online Journal · 2020
    7. Pattern Hair Loss: Assessment of Inflammation and Fibrosis on Histologic Sections Journal of The American Academy of Dermatology · 2019
    8. Progressive Expression of PPARGC1α Is Associated with Hair Miniaturization in Androgenetic Alopecia Scientific Reports · 2019
    9. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    10. Hair Growth Control by Innate Immunocytes: Perifollicular Macrophages Revisited Experimental Dermatology · 2019
    11. The Main Cause of Hair Rarefaction in Androgenetic Alopecia: Higher Number and Longer Duration of Kenogen Hairs Skin appendage disorders · 2018
    12. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors Sexual medicine reviews · 2018
    13. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    14. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    15. Identification of Functional Patterns of Androgenetic Alopecia Using Transcriptome Profiling in Distinct Locations of Hair Follicles Journal of Investigative Dermatology · 2017
    16. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    17. Androgenetic Alopecia: A Review Endocrine · 2017
    18. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    19. Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma Nature medicine · 2015
    20. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    21. The Contribution of Endogenous and Exogenous Factors to Male Alopecia Plastic and Reconstructive Surgery · 2013
    22. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    23. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    24. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    25. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    26. Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis Histopathology · 2009
    27. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    28. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    29. Dermal Fibrosis in Male Pattern Hair Loss: A Suggestive Implication of Mast Cells Archives of Dermatological Research · 2008
    30. Prostanoid Receptors in Anagen Human Hair Follicles Experimental dermatology · 2007
    31. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    32. Vertical vs. Transverse Sections in Alopecia Biopsy Diagnosis The American Journal of Dermatopathology · 2005
    33. Histological Features of Peripilar Signs Associated with Androgenetic Alopecia Archives of Dermatological Research · 2004
    34. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    35. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    36. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    37. Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women Journal of The American Academy of Dermatology · 1996
    38. Male Pattern Alopecia: A Histopathologic and Histochemical Study Journal of Cutaneous Pathology · 1975