The Main Cause of Hair Rarefaction in Androgenetic Alopecia: Higher Number and Longer Duration of Kenogen Hairs

    November 2018 in “ Skin appendage disorders
    Marcella Guarrera, Alfredo Rebora
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    TLDR More kenogen hairs cause hair thinning in androgenetic alopecia, not hair miniaturization.
    This study suggests that the increased duration and frequency of kenogen hairs are the main cause of hair rarefaction in androgenetic alopecia (AGA), rather than hair miniaturization. The study found that oral finasteride increased the total number of hairs by 55%, but failed to decrease the prevalence of vellus hairs. The study involved 43 male subjects with AGA over a 2.5-year period. The study concludes that the old concept of hair miniaturization as the sole possible cause of baldness is hardly tenable, and that the increased duration and frequency of kenogen are the real mechanism through which the scalp hairs rarefy.
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