Pattern Hair Loss: Assessment of Inflammation and Fibrosis on Histologic Sections

    September 2019 in “ Journal of The American Academy of Dermatology ”
    Manuel Valdebran, Joshua H. Mo, Dirk M. Elston, Linda Doan
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    TLDR Inflammation and fibrosis are not significantly different in pattern hair loss compared to controls.
    The study aimed to assess the presence and degree of inflammation and fibrosis in pattern hair loss (PHL) by examining histological sections from 37 PHL cases and comparing them with 45 control scalp excisions. Inflammation was found in 73% of PHL cases and 84% of control cases, while fibrosis was present in 68% of PHL cases and 82.2% of control cases. The study did not find significant differences between the two groups regarding inflammation and fibrosis, challenging the notion that these factors play a significant role in the pathogenesis of PHL. The authors suggest that further research with larger and age-matched controls is necessary to draw more definitive conclusions.
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