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GlossaryTissue Sectioning (Histological Sectioning)

process of cutting thin tissue slices for microscopic examination

Tissue sectioning, also known as microtomy, is the process of cutting thin slices of biological tissue for examination under a microscope. This technique is crucial for studying the detailed structure of tissues, diagnosing diseases, and conducting research. The thin sections, typically only a few micrometers thick, allow for the visualization of cellular and subcellular components when stained and viewed under a microscope.

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research Pattern Hair Loss: Assessment of Inflammation and Fibrosis on Histologic Sections

7 citations , September 2019 in “Journal of The American Academy of Dermatology”

Inflammation and fibrosis are not significantly different in pattern hair loss compared to controls.

research A Study of Serial Vertical Sectioning of Scalp Biopsies to Increase the Histological Diagnostic Yield in Alopecias

9 citations , November 2009 in “Journal of the European Academy of Dermatology and Venereology”

Cutting scalp biopsies in consecutive slices improves diagnosis of hair loss conditions.

research Hair Follicle Group And Skin Follicle Population Of Australian Merino Sheep

116 citations , January 1957 in “Australian Journal of Agricultural Research”

Certain hair follicle traits in Merino sheep may be inherited.

research Elastic Tissue in Scars and Alopecia

80 citations , March 2000 in “Journal of cutaneous pathology”

The VVG stain effectively differentiates scar tissue from normal skin and helps classify types of permanent alopecia.

research On the Use of Micro-Imager to Directly Visualize Drug Distribution in Human Skin

13 citations , January 2001 in “Skin pharmacology and physiology”

Micro-Imager® helps see how drugs spread in human skin.

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community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 6 months ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community It works. About a 1 year transformation.

in Progress Pictures 613 upvotes 2 years ago

A user's experience with hair loss treatments, specifically Minoxidil and finasteride, which they have used without side effects for a year. Other users shared their experiences and advice about potential side effects and supplements to help.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 415 upvotes 5 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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