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    UTX (KDM6A) Promotes Differentiation Noncatalytically in Somatic Self-Renewing Epithelia

    May 2025 in “ Proceedings of the National Academy of Sciences ”
    Gina Pacella, Nina Kuprasertkul, L. Bao … Brian C. Capell
    Studysummary In this study, researchers found that the histone demethylase UTX is crucial for regulating skin differentiation through retinoic acid signaling, mainly impacting females, as males compensate with a Y-linked paralog.
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    Research cited in this study 7

    1. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    2. Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices Science · 2024
    3. Mettl3-Catalyzed m6A Regulates Histone Modifier and Modification Expression in Self-Renewing Somatic Tissue Science Advances · 2023
    4. The Role of Sex and Gender in Dermatology: From Pathogenesis to Clinical Implications Journal of Cutaneous Medicine and Surgery · 2023
    5. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021
    6. Endogenous Retinoids in the Hair Follicle and Sebaceous Gland Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2011
    7. Effect of Retinoids on Follicular Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993