TLDR UTX is crucial for skin differentiation and health, especially in females.
This study examines the role of UTX (KDM6A) in skin differentiation, emphasizing its noncatalytic functions in regulating retinoic acid (RA) signaling, which is crucial for skin homeostasis. The research shows that UTX is essential for activating skin differentiation gene expression, with its absence leading to disrupted epidermal, sebaceous, and hair follicle differentiation, particularly in females due to compensation by the Y-linked paralog UTY in males. UTX deficiency results in a sex-biased cutaneous phenotype, including skin reddening, hair thinning, and epidermal hyperplasia in females. The study highlights the loss of H3K27 acetylation and impaired RA signaling, suggesting UTX's role as a key epigenetic regulator. These findings provide insights into potential therapeutic pathways for skin diseases and underscore the importance of UTX in maintaining skin health.
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1 citations,
March 2024 in “Science” Vitamin A helps skin stem cells decide their function, aiding in hair growth and wound repair.
22 citations,
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50 citations,
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15 citations,
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182 citations,
August 2016 in “Development” ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.
20 citations,
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1 citations,
March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.
February 2024 in “Future science OA” Loss of the Y chromosome and UTY gene activity increases cancer risk in men.
February 2024 in “Brain research bulletin” Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.
