Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

This study investigates the potential of Platycladi Cacumen (PC), a traditional herb, in treating androgenetic alopecia (AGA) through network pharmacology, molecular docking, and molecular dynamics simulation. Researchers identified 32 active components and 439 targets, with quercetin, apigenin, myricetin, and hinokinin as key components. Important targets include ESR1, BCL2, INS, AR, and STAT3. The study suggests that PC may affect AGA by regulating pathways such as the HIF-1 signaling pathway. Molecular docking and dynamics simulations showed stable binding of key components to targets, indicating PC's potential efficacy in AGA intervention.