Terminalia Bellirica (Gaertn.) Roxb. Extracts Reshape the Perifollicular Microenvironment and Regulate the MAPK Pathway for Androgenetic Alopecia Treatment
September 2024
in “
Journal of Ethnopharmacology
”
Terminalia bellirica androgenetic alopecia perifollicular microenvironment MAPK pathway Human Umbilical Vein Endothelial Cells testosterone-induced AGA hair regrowth minoxidil chemical constituents active components scavenging ROS VEGF levels cell migration type II 5α-reductase telogen phase anagen phase oxidative stress angiogenesis TBR AGA HUVECs Rogaine reactive oxygen species vascular endothelial growth factor
TLDR Terminalia bellirica extracts effectively promote hair regrowth and treat androgenetic alopecia.
The study investigates the effects of Terminalia bellirica (TBR) extracts on androgenetic alopecia (AGA). Using human umbilical vein endothelial cells and testosterone-induced AGA mice, the research identifies 28 chemical constituents in TBR, with 15 predicted as active components. TBR significantly promotes hair regrowth by scavenging reactive oxygen species, enhancing VEGF levels, and inhibiting type II 5α-reductase activity. The treatment effectively transitions hair follicles from the telogen to anagen phase by modulating the MAPK pathway, reducing oxidative stress, and increasing angiogenesis. The findings suggest TBR as a promising alternative to current AGA treatments like minoxidil.
