In Silico Analysis of Berberine as a Potential Therapeutic Approach for Various Signaling Pathways Linked to Androgenetic Alopecia

July 2024 in “ Recent Advances in Inflammation & Allergy Drug Discovery ”

Sagarika Majhi, Chaitanya Vinayak, Iti Chauhan, Madhu Verma, Sourabh Sharma

berberine androgenetic alopecia 5α-reductase TGF-β2 minoxidil Lipinski's rule of five ADMET properties male pattern baldness Rogaine

TLDR Berberine may be a safe and effective treatment for male pattern baldness.

The study investigates berberine as a potential treatment for androgenetic alopecia through in silico analysis. Berberine was found to effectively bind to 5α-reductase and TGF-β2, key proteins involved in hair loss, with docking scores of -8.4 and -7.1, respectively, outperforming minoxidil. The compound adheres to Lipinski's rule of five and shows favorable ADMET properties, indicating good drug-likeness and minimal toxicity risk. The findings suggest that berberine could be a promising therapeutic agent for male pattern baldness by regulating TGF-β2 and 5α-reductase activity.

View this study on eurekaselect.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 8 results

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 4 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Do we have to be junkies? That's funny

in Research/Science 13 upvotes 5 months ago

The conversation discusses using finasteride, dutasteride, minoxidil, cialis, and metformin to protect hair and health. Some users caution against self-prescribing these drugs due to potential risks and complications.

community One+ year 1mg Fin, Ketoconazole, and 3.75 Oral Min. I have DUPA. Switched from Topical to Oral Min.

in Progress Pictures 142 upvotes 2 years ago

A user's experience with hair loss treatments such as finasteride, ketoconazole, and oral minoxidil that have not yielded any results; other users suggest shaving the head or getting a wig, while others offer additional advice such as seeing a dermatologist, checking thyroid levels, switching to dutasteride and adding needling, and trying stemoxydine.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

in Female 53 upvotes 1 year ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

community A science based addition to your hair loss routine

in Research/Science 23 upvotes 5 months ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

Similar Research

5 / 166 results

research An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing the Big Eight Strikes

July 2023 in “Cosmetics”

New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.

The New Paradigm for Androgenetic Alopecia and Plant-Based Folk Remedies: 5α-Reductase Inhibition, Reversal of Secondary Microinflammation, and Improving Insulin Resistance

research The New Paradigm for Androgenetic Alopecia and Plant-Based Folk Remedies: 5α-Reductase Inhibition, Reversal of Secondary Microinflammation, and Improving Insulin Resistance

16 citations, September 2018 in “Journal of Ethnopharmacology”

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

research The 'Bald' Phenotype (Androgenetic Alopecia) Is Caused by the High Glycemic, High Cholesterol, and Low Mineral 'Western Diet'

7 citations, June 2021 in “Trends in Food Science and Technology”

Western diet may cause male pattern baldness; low glycemic diet with magnesium could help.

research Edible Seeds From Cucurbitaceae Family as Potential Functional Foods: Immense Promises, Few Concerns

54 citations, May 2017 in “Biomedicine & Pharmacotherapy”

Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.

research Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome

October 2023 in “Frontiers in endocrinology”

Effective PCOS treatments require targeting specific signaling pathways.