Terminalia Chebula Retz. Fruit Extract Promotes Murine Hair Growth by Suppressing 5α-Reductase and Accelerating the Degradation of Dihydrotestosterone

October 2025 in “ Biomedicines ”

Ting Cui, Xiaoqing Wang, Qi Wu, Ye Zhong, Wang Feng-lou, Yue Zou, Yushu Wang, Shanshan Jiang, Gang Ma

Terminalia chebula Terminalia chebula fruit extract androgenetic alopecia 5α-reductase dihydrotestosterone Wnt/β-catenin signaling pathway TGF-β signaling pathway dermal papilla cells finasteride TCFE AGA DHT

TLDR Terminalia chebula fruit extract helps hair growth by reducing DHT and boosting hair cell activity.

The study explores the effects of Terminalia chebula fruit extract (TCFE) on hair growth, particularly for treating androgenetic alopecia (AGA). TCFE was found to promote hair growth by activating Wnt/β-catenin and TGF-β signaling pathways in dermal papilla cells (DPCs), inhibiting type II 5α-reductase activity, and enhancing dihydrotestosterone (DHT) metabolism. In a mouse model of AGA, TCFE effectively reversed hair loss and promoted regrowth, showing efficacy similar to finasteride but through different mechanisms. The study suggests TCFE as a promising natural treatment for AGA, though further research is needed to identify specific active components and their molecular mechanisms.

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