Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

This study explores the potential of Platycladi Cacumen (PC) in treating androgenetic alopecia (AGA) using network pharmacology, molecular docking, and molecular dynamics simulation. The research identified 32 active components and 439 targets, with quercetin, apigenin, myricetin, and hinokinin as key components. Key targets such as ESR1, BCL2, INS, AR, and STAT3 were identified through protein-protein interaction analysis. The study suggests that PC may influence AGA by regulating pathways like the EGFR receptor and HIF-1 signaling. Molecular docking and dynamics simulations confirmed strong binding stability of the key components with core targets, indicating PC's potential as a natural intervention for AGA.