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GlossaryEstrogen Receptor Alpha (ESR1)

protein inside cells that binds to estrogen hormone

Estrogen Receptor Alpha (ERα) is a protein found inside cells that binds to the hormone estrogen. This receptor is crucial for regulating various biological processes, including reproductive functions and the development of certain tissues. In the context of hair and alopecia, ERα can influence hair growth and loss, as estrogen plays a role in the hair growth cycle.

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research Comparative Transcriptome Profiling of Hair Follicles from Forest Musk Deer at Different Stages

November 2022 in “Research Square (Research Square)”

The research provides insights into hair follicle growth in forest musk deer by identifying key genes and pathways involved.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Expansion of Specialized Epidermis Induced by Hormonal State and Mechanical Strain

3 citations , February 2015 in “Mechanisms of development”

Hormones and stretching both needed for nipple area skin growth in mice.

research Sesamin Alleviates Androgenetic Alopecia by Targeting the AR MAPK Wnt Axis

January 2026 in “Scientific Reports”

Sesamin may help treat hair loss by affecting specific cell pathways.

research Expression Patterns of Three Estrogen Receptor Genes During Zebrafish Development: Evidence for High Expression in Neuromasts

77 citations , April 2004 in “Gene expression patterns”

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

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community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 1 year ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community Dutasteride Literally Saves Your Hair

in Finasteride/Dutasteride 101 upvotes 1 year ago

Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.