Suicidality Risks Associated with Finasteride, a 5-Alpha Reductase Inhibitor: An Evaluation of Real-World Data from the FDA Adverse Event Reports

    June 2025 in “ Pharmaceuticals ”
    Hilal A. Thaibah, Otilia J.F. Banji, David Banji … Thamir M. Alshammari
    Studysummary This study analyzed reports from the FDA Adverse Event Reporting System and observed an upward trend in suicidality-related safety signals among young male finasteride users since 2019, peaking in 2022, highlighting emerging psychiatric safety concerns and the need for vigilant monitoring of this population.
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    Research cited in this study 23

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    2. The Risk of Psychiatric Disorders in Finasteride Users With Benign Prostatic Hyperplasia and Androgenetic Alopecia: A Population-Based Case-Control Study Australasian Journal of Dermatology · 2024
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    19. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
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    Related research 4

    1. Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review Brazilian Journal of Hair Health · 2024
    2. 5 Alpha-Reductase and Finasteride in Pattern Alopecia and Acne PubMed · 2004
    3. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    4. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992