The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption

    July 2018 in “ Current Sexual Health Reports ”
    Abdulmaged M. Traish
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    TLDR Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.
    The document discusses the Post-finasteride Syndrome (PFS), a set of persistent adverse effects that can occur after discontinuing the use of finasteride, a drug used to treat hair loss and benign prostatic hyperplasia. The paper cites several studies that have shown that finasteride can cause sexual dysfunction, depression, and other adverse effects that can persist even after discontinuing the drug. The paper also discusses the possible mechanisms by which finasteride can cause these adverse effects, including epigenetic changes and endocrine disruption. The authors suggest that more research is needed to fully understand the long-term effects of finasteride and to develop effective treatments for PFS.
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      community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

      in Research/Science  8 upvotes 4 months ago
      Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

      community 1 month of using fin, so happy

      in Progress Pictures  863 upvotes 8 months ago
      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 1 year ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

      community Male pattern baldness, and mental health

      in Finasteride/Dutasteride  332 upvotes 1 year ago
      A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

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