The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption

The document discusses the Post-finasteride Syndrome (PFS), a set of persistent adverse effects that can occur after discontinuing the use of finasteride, a drug used to treat hair loss and benign prostatic hyperplasia. The paper cites several studies that have shown that finasteride can cause sexual dysfunction, depression, and other adverse effects that can persist even after discontinuing the drug. The paper also discusses the possible mechanisms by which finasteride can cause these adverse effects, including epigenetic changes and endocrine disruption. The authors suggest that more research is needed to fully understand the long-term effects of finasteride and to develop effective treatments for PFS.