Exposure of Xenopus Laevis Tadpoles to Finasteride, an Inhibitor of 5-Alpha Reductase Activity, Impairs Spermatogenesis and Alters Hypophyseal Feedback Mechanisms

    June 2009 in “ Journal of Molecular Endocrinology ”
    Ralph Urbatzka, Burkard Watermann, Ilka Lutz, Werner Kloas
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    TLDR Finasteride exposure harms tadpole reproduction and hormone balance.
    Exposure of Xenopus laevis tadpoles to finasteride, an inhibitor of 5-α reductase activity, impairs spermatogenesis and alters hypophyseal feedback mechanisms. The study found that exposure to finasteride led to a decrease in testicular size and sperm count, as well as changes in the levels of hormones involved in the hypothalamic-pituitary-gonadal axis. These findings suggest that finasteride may have negative effects on reproductive function in amphibians.
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