Exposure of Xenopus Laevis Tadpoles to Finasteride, an Inhibitor of 5-Alpha Reductase Activity, Impairs Spermatogenesis and Alters Hypophyseal Feedback Mechanisms

    June 2009 in “ Journal of Molecular Endocrinology ”
    Ralph Urbatzka, Burkard Watermann, Ilka Lutz, Werner Kloas
    Studysummary This study found that exposure to finasteride impaired spermatogenesis in male Xenopus laevis by affecting sex-specific feedback mechanisms in the hypothalamus–pituitary–gonad axis.
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    Research cited in this study 8

    1. 5-Alpha-Reductase 2 Inhibition Impairs Brain Defeminization of Male Rats: Reproductive Aspects Pharmacology Biochemistry and Behavior · 2005
    2. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    3. Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats BJUI · 2002
    4. Proscar (Finasteride) Inhibits 5α-Reductase Activity in the Ovaries and Testes of Lytechinus Variegatus Lamarck (Echinodermata: Echinoidea) Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology · 1998
    5. Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1998
    6. Effects of Finasteride, a Type 2 5-Alpha Reductase Inhibitor, on Fetal Development in the Rhesus Monkey (Macaca Mulatta) Teratology · 1997
    7. Effect of Finasteride on Human Testicular Steroidogenesis PubMed · 1996
    8. Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism Fundamental and applied toxicology · 1994

    Related research 1

    1. Exposure of Xenopus Laevis Tadpoles to Finasteride, an Inhibitor of 5-Alpha Reductase Activity, Impairs Spermatogenesis and Alters Hypophyseal Feedback Mechanisms Journal of Molecular Endocrinology · 2009