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GlossaryPost-Finasteride Syndrome (PFS)

condition with persistent side effects after stopping finasteride

Post-Finasteride Syndrome (PFS) is a condition that some individuals experience after discontinuing the use of finasteride, a medication commonly prescribed for hair loss and benign prostatic hyperplasia. Symptoms can include persistent sexual dysfunction, depression, anxiety, and cognitive impairments, which may continue for months or even years after stopping the drug. The exact cause of PFS is not well understood, and it remains a topic of ongoing research and debate within the medical community.

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Research

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Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System

research Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System

July 2025 in “International Journal of Dermatology”

Topical finasteride may be safer than oral finasteride, but more research is needed.

research Discriminating in Favor of or Against Men with Increased Risk of Finasteride-Related Side Effects?

2 citations , August 2016 in “Experimental Dermatology”

Finasteride treats baldness but may cause lasting sexual side effects.

research Post Finasteride Syndrome: Demographics from FDA Database

April 2016 in “The Journal of Sexual Medicine”

Younger people (median age 35) experience more PFS-like symptoms with 1mg finasteride; more research needed.

research Biofeedback Treatment for Dysfunctional Voiding Diagnosed in Adulthood

September 2011 in “Urology”

Biofeedback treatment for dysfunctional voiding in adults showed no symptom improvement.

research Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians

30 citations , January 2020 in “Fertility and Sterility”

Finasteride can cause serious side effects in some men, needing more research for treatment.

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Community Join

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community How the average guy dont care about balding?

in Research/Science 128 upvotes 4 years ago

Many people experience hair loss but don't treat it. Common treatments include Minoxidil, Finasteride, and microneedling.

community Diagnosed with MPB. Started with finastride 1mg

in Finasteride/Dutasteride 18 upvotes 2 years ago

A 28-year-old male diagnosed with Male Pattern Baldness is using finasteride 1mg and asking if it's sufficient without minoxidil, PRP, or multivitamins. The advice given is to continue with finasteride and assess results after a year before considering additional treatments.

community The closest thing to a cure before hair cloning or genetic via?

in Treatment 9 upvotes 3 years ago

The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

community Pryri journey update 2 weeks so far.

in Treatment 15 upvotes 3 years ago

A 2-week journey with Pyri, which is producing positive effects on hair texture and reduced shedding; Minoxidil and derma needling are being used as treatments.

community 27m gone bald, hair in 2018 to no hair 2024 considering HT

in Shaved/buzzed 172 upvotes 1 year ago

A 27-year-old considering a hair transplant after going bald from 2018 to 2024. Recommendations include using finasteride and minoxidil before the transplant, with mixed opinions on their long-term use and side effects.

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