The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

January 2009 in “ Sexual Development ”

Paula Duarte-Guterman, Valerie S. Langlois, Kathleen Hodgkinson, Bruce D. Pauli, Graham S Cooke, M. R. Wade, Vance L. Trudeau

aromatase inhibitor Fadrozole 5-Reductase inhibitor Finasteride gonadal differentiation gene expression intersex thyroid hormones THs Propecia

TLDR Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

The study investigated the effects of the aromatase inhibitor Fadrozole and the 5-Reductase inhibitor Finasteride on gonadal differentiation and gene expression in the frog Silurana tropicalis. The results showed that chronic exposure to Fadrozole and Finasteride affected gonadal differentiation by altering sex ratios and inducing intersex animals. Gene expression analyses confirmed that chemically-induced intersex animals display different gene expression profiles depending on the mode of action of the pollutant. The study also found that Finasteride treatment results in an increased capacity for hepatic activation of thyroid hormones (THs) while decreasing the inactivation pathway in males and intersex.

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Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development

research Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development

60 citations, April 2010 in “General and Comparative Endocrinology”

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

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