Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development

November 2009 in “ General and Comparative Endocrinology ”

Valerie S. Langlois, Paula Duarte-Guterman, Sally Ing, Bruce D. Pauli, Gerard M. Cooke, Vance L. Trudeau

fadrozole finasteride sex steroids thyroid hormones gene expression Silurana tropicalis Xenopus tropicalis enzyme inhibition transcription reproductive axis thyroid axis embryogenesis Propecia

Studysummary The researchers reported that during early embryogenesis and larval development in Silurana tropicalis, inhibiting steroidogenic enzymes cyp19 and srd5beta affects genes related to thyroid and reproductive systems.

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The study investigated the effects of fadrozole and finasteride on gene expression related to sex steroids and thyroid hormones during early larval development in Silurana (Xenopus) tropicalis. The results showed that inhibiting these enzymes affected the transcription of sex steroid- and thyroid hormone-related genes. The study suggests a complex interaction between the developing reproductive and thyroid axes during amphibian embryogenesis.

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