Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development

April 2010 in “ General and Comparative Endocrinology ”

Valerie S. Langlois, Paula Duarte-Guterman, Sally Ing, Bruce D. Pauli, Gerard M. Cooke, Vance L. Trudeau

fadrozole finasteride sex steroids thyroid hormones gene expression Silurana tropicalis Xenopus tropicalis enzyme inhibition transcription reproductive axis thyroid axis embryogenesis Propecia

TLDR Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

The study investigated the effects of fadrozole and finasteride on gene expression related to sex steroids and thyroid hormones during early larval development in Silurana (Xenopus) tropicalis. The results showed that inhibiting these enzymes affected the transcription of sex steroid- and thyroid hormone-related genes. The study suggests a complex interaction between the developing reproductive and thyroid axes during amphibian embryogenesis.

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