Transcriptomic Profiling in Silurana Tropicalis Testes Exposed to Finasteride

February 2014 in “ General and Comparative Endocrinology ”

Sonja Bissegger, Christopher J. Martyniuk, Valerie S. Langlois

finasteride testosterone 5α-DHT reproduction apoptosis metabolism biosynthesis immune response cell communication cell growth differentiation epigenetics Propecia DHT cell differentiation

Studysummary In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.

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research Exposure of Xenopus Laevis Tadpoles to Finasteride, an Inhibitor of 5-Alpha Reductase Activity, Impairs Spermatogenesis and Alters Hypophyseal Feedback Mechanisms

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