Transcriptomic Profiling in Silurana Tropicalis Testes Exposed to Finasteride

    February 2014 in “ General and Comparative Endocrinology ”
    Sonja Bissegger, Christopher J. Martyniuk, Valerie S. Langlois
    Studysummary In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.
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    Research cited in this study 5

    1. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    2. Expression Profiles of Reproduction and Thyroid Hormone Related Transcripts in the Brains of Chemically Induced Intersex Frogs Sexual Development · 2011
    3. Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development General and Comparative Endocrinology · 2009
    4. Exposure of Xenopus Laevis Tadpoles to Finasteride, an Inhibitor of 5-Alpha Reductase Activity, Impairs Spermatogenesis and Alters Hypophyseal Feedback Mechanisms Journal of Molecular Endocrinology · 2009
    5. The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis Sexual Development · 2009

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992