Transcriptomic Profiling in Silurana Tropicalis Testes Exposed to Finasteride
February 2014
in “
General and Comparative Endocrinology
”
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Studysummary In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.
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This study investigated the effects of finasteride on Silurana tropicalis testes. The researchers found that finasteride exposure increased the production of testosterone and decreased the production of 5α-DHT in both liver and testis tissues. The study also identified a number of gene ontology terms that were significantly enriched after finasteride exposure, including those involved in reproduction, apoptosis, metabolism, biosynthesis, immune response, cell communication, cell growth and differentiation, and epigenetics. The study suggests that finasteride can have adverse effects on the reproductive system at the molecular, cellular, and physiological levels. Further experiments should be undertaken to investigate these findings in detail.
