Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

March 2018 in “ International journal of molecular sciences ”

Carmen J. Zamora-Sánchez, Aylin Del Moral-Morales, Ana M. Hernández-Vega, Valeria Hansberg-Pastor, Iván Salido-Guadarrama, Mauricio Rodríguez-Dorantes, Ignacio Camacho‐Arroyo

allopregnanolone progesterone finasteride 3α-THP P4 F

TLDR Allopregnanolone changes gene expression in glioblastoma cells.

The study investigated the effects of allopregnanolone (3α-THP), progesterone (P4), and finasteride (F) on gene expression in U87 human glioblastoma cells, revealing that 3α-THP significantly altered 137 genes, F changed 90, and P4 modified only six. Both 3α-THP and F up-regulated genes involved in DNA integrity, replication, and cytoskeleton reorganization. The study validated changes in 10 selected genes, with 3α-THP up-regulating six. Combined treatments showed distinct gene expression changes, suggesting F modulates the effects of P4 and 3α-THP. The findings highlighted the potential of 3α-THP and F in influencing glioblastoma cell behavior and suggested further research to explore their clinical applications.

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