155 citations
,
October 2002 in “The FASEB Journal” This study found that altered testosterone metabolism and changes in cytochrome P450 mono-oxygenase expression are significantly associated with cardiac hypertrophy in human hearts and spontaneously hypertensive rats.
62 citations
,
January 2009 in “Epilepsia” In this study, status epilepticus in rats induced P450scc in hippocampal glia, which was associated with a delayed onset of spontaneous seizures, while inhibiting neurosteroid synthesis accelerated seizure onset if P450scc was significantly increased.
4 citations
,
September 1994 in “Xenobiotica” Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.
3 citations
,
January 2018 in “Archives of Disease in Childhood” In this study, researchers at Nottingham Children's Renal Unit found that most pediatric patients switching from Prograf to the generic tacrolimus preparation Adoport maintained stable tacrolimus levels and therapeutic effectiveness, supporting Adoport's use as a cost-saving alternative for the NHS.
1 citations
,
September 2022 in “Rheumatology Advances in Practice” This case report highlights a rare instance of costovertebral arthritis secondary to Systemic Lupus Erythematosus, emphasizing the importance of detailed clinical evaluation and imaging for accurate diagnosis and management of chronic back and chest pain.