Evaluation of the 5α-Reductase Inhibitor Finasteride on Reproduction and Gonadal Development in Medaka, Oryzias Latipes

    April 2015 in “ General and Comparative Endocrinology ”
    Michael D. Lee, Jana R. Loux-Turner, Kenneth Oliveira
    Studysummary Finasteride negatively affects fish reproduction and gonadal development.
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    Research cited in this study 8

    1. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    2. Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development General and Comparative Endocrinology · 2009
    3. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    4. The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis Sexual Development · 2009
    5. Discovery and Clinical Development of Dutasteride, a Potent Dual 5α-Reductase Inhibitor Current topics in medicinal chemistry · 2006
    6. Androgen Binding Profiles of Two Distinct Nuclear Androgen Receptors in Atlantic Croaker (Micropogonias Undulatus) The Journal of Steroid Biochemistry and Molecular Biology · 2000
    7. Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism Fundamental and applied toxicology · 1994
    8. The Clinical Development of a 5α-Reductase Inhibitor, Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1990

    Related research 2

    1. Suppression of Spermatogenesis with Desogestrel and Testosterone Pellets Is Not Enhanced by Addition of Finasteride PubMed · 2001
    2. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992