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The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

37 citations , January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

research Temporal Expression and Steroidal Regulation of piRNA Pathway Genes (Mael, Piwi, Vasa) During Silurana (Xenopus) Tropicalis Embryogenesis and Early Larval Development

23 citations , April 2010 in “Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology”

The piRNA pathway genes are crucial in early development and may influence sex differentiation through hormone regulation.

research Gonadal Dysgenesis and Bone Metabolism

45 citations , February 2001 in “Joint bone spine”

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

research Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

18 citations , October 2021 in “Frontiers in Physiology”

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

research Transcriptomic Profiling in Silurana Tropicalis Testes Exposed to Finasteride

8 citations , February 2014 in “General and Comparative Endocrinology”

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

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community Takes time my friends, years in fact

in Satire 53 upvotes 2 years ago

The conversation discusses long-term hair loss treatment, with one person seeing hair darkening after 3 years using Minoxidil, Finasteride, and Dutasteride, and others sharing their shorter-term experiences with similar treatments. They emphasize that hair regrowth takes time and to not expect quick results.

community How does hair loss and recovery work?

in Chat 12 upvotes 1 year ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community Do you/can you use ketoconazole shampoo continuously?

in Ketoconazole 9 upvotes 1 year ago

A dermatologist prescribed 2% ketoconazole shampoo for hair loss, advising against continuous use beyond 6 weeks. Users discussed potentially using the 1% version regularly, with a recommendation of 1 or 2 times a week.

community Possible "Cure" For Pos Finasteride Syndrome

in Chat 6 upvotes 5 years ago

A user reported full recovery from Post Finasteride Syndrome after 6 months of HCG treatment. They used 250IU of HCG three times a week.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 2 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

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