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    Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review

    July 2023 in “ Dermatology and Therapy ”
    Mariana Escamilla-Cruz, Mario Magaña, Sabrina Escandón-Pérez, Omar Yaxmehen Bello‐Chavolla
    Studysummary This review analyzed the use of 5-alpha reductase inhibitors (5ARIs) for treating various dermatological conditions such as androgenetic alopecia, acne, and hirsutism, emphasizing their efficacy and safety profile.
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    Research cited in this study 31

    1. Efficacy, Tolerability, and Safety of Montelukast Versus Finasteride for the Treatment of Moderate Acne in Women: A Prospective, Randomized, Single-Blinded, Active-Controlled Trial Journal of Cosmetic Dermatology · 2021
    2. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    3. Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Journal of Dermatological Treatment · 2020
    4. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    5. Androgens in Women: Hormone-Modulating Therapies for Androgen-Mediated Cutaneous Disorders Journal of The American Academy of Dermatology · 2018
    6. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study American Journal of Clinical Dermatology · 2018
    7. The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption Current Sexual Health Reports · 2018
    8. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    9. 5-Alpha-Reductase Inhibitor Treatment for Frontal Fibrosing Alopecia: An Evidence-Based Treatment Update JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2018
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    14. A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers International Journal of Clinical Pharmacology and Therapeutics · 2014
    15. Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients Journal of The American Academy of Dermatology · 2014
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    17. Finasteride 5 mg/Day Treatment of Patterned Hair Loss in Normo-Androgenetic Postmenopausal Women International Journal of Trichology · 2013
    18. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
    19. Effect of Finasteride 5 mg (Proscar) on Acne and Alopecia in Female Patients with Normal Serum Levels of Free Testosterone Gynecological Endocrinology · 2007
    20. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    21. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    22. Efficacy and Tolerability of Finasteride 1 mg in Men Aged 41 to 60 Years with Male Pattern Hair Loss PubMed · 2003
    23. Treatment of Hyperandrogenic Alopecia in Women Fertility and Sterility · 2003
    24. Hair Loss in Women with Hyperandrogenism: Four Cases Responding to Finasteride Journal of The American Academy of Dermatology · 2002
    25. Comparison of High-Dose Finasteride (5 mg/day) Versus Low-Dose Finasteride (2.5 mg/day) in the Treatment of Hirsutism European journal of endocrinology · 2002
    26. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    27. Long-Term Multinational Experience with Finasteride 1 mg in the Treatment of Men with Androgenetic Alopecia PubMed · 2002
    28. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    29. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    30. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    31. Finasteride The New England Journal of Medicine · 1994

    Related research 5

    1. Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review Dermatology and Therapy · 2023
    2. Luncheon Symposium: Update on the Efficacy and Safety of Dutasteride in the Management of Androgenetic Alopecia 프로그램북(구 초록집) · 2015
    3. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    4. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    5. Finasteride The New England Journal of Medicine · 1994